Androgen deprivation therapy and diet: what is the evidence?

Prostate cancer is the most common cancer in men. With advances in medical therapy, more and more patients are being put on androgen deprivation therapy. Literature demonstrates men undergoing surgery for prostate cancer have significant unmet needs. However, as yet, no systematic review has examined diet and diabetes. Adult males (≥18, <55 years) AND Prostate cancer AND Androgen deprivation therapy with dietary supplements, dietary control and diabetes. Intervention: ADT, dietary supplements, diabetes, dietary supplements and lycopene. Experimental vs. Control, Experimental vs. Experimental, Control vs. control. Primary outcomes: Benefit: Improvement in side effects. Harm: Adverse events following treatment. Secondary outcomes: BFRR Suvival outcomes. To assess mens’ needs regarding diet and diabetes when on androgen deprivation therapy. A systematic review was conducted of prostate cancer and androgen deprivation therapy, to investigate role of diet and diabetes in androgen deprivation therapy. The systematic review elicited over 580 papers, 10 of which conformed to the search criteria. The dietary requirements were identified from the systematic review by patients as an unmet need. Additionally, very few papers addressed dietary interventions for diabetes when on ADT. These findings were confirmed by existing systematic reviews and conference papers. This systematic review demonstrated a large unmet need for dietary and diabetic care in men on ADT. Poor health related quality of life was also associated with men on ADT, within the systematic review. This study strives to explore dietary and diabetic needs, and subsequent development and implementation of an intervention to address these needs.